Publications for Knee Cartilage Repair Indication

Phase II Randomized Clinical Trial

Hoburg, Arnd, et al. "Safety and efficacy of matrix-associated autologous chondrocyte implantation with spheroids for patellofemoral or tibiofemoral defects: a 5-year follow-up of a phase 2, dose-confirmation trial." Orthopaedic Journal of Sports Medicine 10.1 (2022): 23259671211053380.

Link: https://pubmed.ncbi.nlm.nih.gov/35071653/

Eschen, C., et al. "Clinical outcome is significantly better with spheroid-based autologous chondrocyte implantation manufactured with more stringent cell culture criteria." Osteoarthritis and Cartilage Open 2.1 (2020): 100033.

Link: https://pubmed.ncbi.nlm.nih.gov/36474562/

Niemeyer, Philipp, et al. "Clinical outcome and success rates of ACI for cartilage defects of the patella: a subgroup analysis from a controlled randomized clinical phase II trial (CODIS study)." Archives of Orthopaedic and Trauma Surgery 140 (2020): 717-725.

Link: https://pubmed.ncbi.nlm.nih.gov/31451902/

Niemeyer, Philipp, et al. "Safety and efficacy of matrix-associated autologous chondrocyte implantation with spheroid technology is independent of spheroid dose after 4 years." Knee Surgery, Sports Traumatology, Arthroscopy 28 (2020): 1130-1143.

Link: https://pubmed.ncbi.nlm.nih.gov/31897548/

Hoburg, Arnd, et al. "Matrix-associated autologous chondrocyte implantation is an effective treatment at midterm follow-up in adolescents and young adults." Orthopaedic Journal of Sports Medicine 7.4 (2019): 2325967119841077.

Link: https://pubmed.ncbi.nlm.nih.gov/31041335/

Becher, Christoph, et al. "Safety of three different product doses in autologous chondrocyte implantation: results of a prospective, randomised, controlled trial." Journal of orthopaedic surgery and research 12.1 (2017): 1-9.

Link: https://pubmed.ncbi.nlm.nih.gov/28499391/

Niemeyer, Philipp, et al. "The effect of cell dose on the early magnetic resonance morphological outcomes of autologous cell implantation for articular cartilage defects in the knee: a randomized clinical trial." The American Journal of Sports Medicine 44.8 (2016): 2005-2014.

Link: https://pubmed.ncbi.nlm.nih.gov/27206690/

Phase III Randomized Clinical Trial

Hoburg, Arnd, et al. "Sustained superiority in KOOS subscores after matrix-associated chondrocyte implantation using spheroids compared to microfracture." Knee Surgery, Sports Traumatology, Arthroscopy 31.6 (2023): 2482-2493.

Link: https://pubmed.ncbi.nlm.nih.gov/36269383/

Hoburg, Arnd, et al. "Matrix-associated autologous chondrocyte implantation with spheroid technology is superior to arthroscopic microfracture at 36 months regarding activities of daily living and sporting activities after treatment." Cartilage 13.1_suppl (2021): 437S-448S.

Link: https://pubmed.ncbi.nlm.nih.gov/31893951/

Niemeyer, Philipp, et al. "A prospective, randomized, open-label, multicenter, phase III noninferiority trial to compare the clinical efficacy of matrix-associated autologous chondrocyte implantation with spheroid technology versus arthroscopic microfracture for cartilage defects of the knee." Orthopaedic journal of sports medicine 7.7 (2019): 2325967119854442.

Link: https://pubmed.ncbi.nlm.nih.gov/31317047/